Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy.

作者：Q. Ping Dou, David M. Smith, Kenyon G. Daniel, Aslamuzzaman Kazi · 发表于：PubMed · 年份：2003 · 被引用次数：52 · 研究领域：Ubiquitin and proteasome pathways、Cancer, Lipids, and Metabolism

The ubiquitin/proteasome-dependent protein degradation pathway plays an essential role in both up-regulation of cell proliferation and down-regulation of cell death in human cancer cells. The idea that proteasome function is required for tumor cell survival has prompted the design, synthesis and evaluation of various pharmacological proteasome inhibitors. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of proteasome inhibitors as novel anticancer drugs.