Preoperative inflammation-based markers predict early and late recurrence of hepatocellular carcinoma after curative hepatectomy

作者：Yue Liu, Zhong‐Xia Wang, Yin Cao, Guang Zhang, Weibo Chen, Chunping Jiang · 发表于：Hepatobiliary & pancreatic diseases international · 年份：2016 · DOI：10.1016/s1499-3872(16)60094-2 · 被引用次数：47 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Hepatocellular Carcinoma Treatment and Prognosis、Ferroptosis and cancer prognosis

BACKGROUND: Recurrence of hepatocellular carcinoma (HCC) after curative resection remains a major cause of treatment failure and tumor-related death. Patterns of HCC recurrence can be categorized into early recurrence and late recurrence which have different underlying mechanisms. In this study, we investigated if simple inflammation-based clinical markers can distinguish patterns of recurrence after curative resection of HCC. METHODS: A retrospective analysis of 223 patients who underwent curative hepatectomy for HCC was performed. Preoperative inflammation-based factors including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, gamma-glutamyl transferase/alanine aminotransferase ratio, aspartate aminotransferase/platelet ratio index (APRI) and prognostic nutritional index together with other clinicopathologic parameters were evaluated by univariate analysis and multivariate analysis to identify independent prognostic factors. By combining risk factors, predictive models were established to distinguish populations at high risk of early or late recurrence. RESULTS: Age ≤50 years, resection margin ≤1 cm, TNM stage III-IV, NLR>2.75, APRI>0.23 and positive alpha-fetoprotein were independent adverse prognostic factors for early recurrence. Patients with three or more risk factors were at significant higher risk of early recurrence. APRI>0.23 and positive hepatitis B e antigen (HBeAg) were independent risk factors of late recurrence, the coexistence of high APRI and p...