Impacts of aerosol inhalation of budesonide combined with ambroxol hydrochloride in treating infants with chronic cough caused by pneumonia mycoplasma infection

作者：L Chen · 发表于：Journal of Clinical Medicine in Practice · 年份：2014 · 研究领域：Pediatric health and respiratory diseases、Respiratory viral infections research、Pneumonia and Respiratory Infections

Objective To discuss clinical effect of aerosol inhalation of budesonide combined with ambroxol hydrochloride in treating infants with chronic cough caused by pneumonia mycoplasma infection( PMI). Methods Atotal of 84 infants caused by PMI were randomly divided into observation group and control group with 42 patients in each group. The patients in control group were given azithmmycin anti-infectious treatment and aerosol inhalation of ambroxol hydrochloride while the observation group was added aerosol inhalation of budesonide on the basis of the control group. Eosinophil granulocyte( EOS),immunoglobulin E( IgE) and eosinophil cationic protein( ECP) levels in both groups were observed before and after the treatment. The clinical effect and cough symptomatic scores on the first,the third,the fifth and the seventh days of treatment were compared. Meanwhile,the time of cough relieving and disappearance as well as recurrent within 3 months were recorded in the period of following up visits. Results Cough symptomatic scores were significantly lower,but overall response rate was higher in observation group than in the control group on the first,the third,the fifth and the seventh days of treatment. After treatment,ECP and EOS levels decreased obviously,and IgE increased evidently in both group. The time of cough relieving,disappear time and recurrent time within 3 months were obviously shorter in observation group than in control group. Conclusion Combination of Budesonide and amb...