Mesenchymal stem cells promote pancreatic adenocarcinoma cells invasion by transforming growth factor-β1 induced epithelial-mesenchymal transition

作者：Hai-sen Zhou, Xiao-Fang Su, Xingli Fu, Guo-Zhong Wu, Kunlun Luo, Zheng Fang, Feng Yu, Hong Liu, Hongjuan Hu, Liusheng Chen, Bing Cai, Zhiqiang Tian · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9319 · 被引用次数：21 · 研究领域：Cancer Cells and Metastasis、Mesenchymal stem cell research、Pancreatic and Hepatic Oncology Research

// Hai-Sen Zhou 2, * , Xiao-Fang Su 3, * , Xing-Li Fu 4, * , Guo-Zhong Wu 5 , Kun-Lun Luo 5 , Zheng Fang 5 , Feng Yu 5 , Hong Liu 5 , Hong-Juan Hu 2 , Liu-Sheng Chen 2 , Bing Cai 1 , Zhi-Qiang Tian 1, 5 1 Department of General Surgery, Wuxi People’s Hospital, Nanjing Medical University, Wuxi 214023, P.R. China 2 Nanjing Lishui People’s Hospital, Nanjing 211200, P.R. China 3 Department of Rehabilitation Medicine, The 101st Hospital of Chinese PLA, Wuxi 214044, P.R. China 4 Health Science Center, Jiangsu University, Zhenjiang 212013, P.R. China 5 Department of General Surgery, The 101st Hospital of Chinese PLA, Wuxi 214044, P.R. China * These authors are contributed equally to this work Correspondence to: Zhi-Qiang Tian, email: zhiqiangtiann@163.com Bing Cai, email: caibing@wuxiph.com Keywords: mesenchymal stem cells, pancreatic adenocarcinoma, epithelial-mesenchymal transition, transforming growth factor-β1 Received: December 28, 2015      Accepted: April 25, 2016      Published: May 12, 2016 ABSTRACT Mesenchymal stem cells (MSCs) could be ideal delivery vehicles for antitumor biological agents in pancreatic adenocarcinoma (PA). While the role of MSCs in tumor growth is elusive. Inflammation is an important feature of PA. In this study, we reported that MSCs pre-stimulated with the combination of TNF-α and IFN-γ promote PA cells invasion. The invasion of PA cell lines were evaluate by wound healing ...