Expression of PHD2 and HIF-1α in hepatocellular carcinoma and its clinical significance

作者：YI Jilin · 发表于：Huazhong yixue zazhi · 年份：2008 · 研究领域：Cancer, Hypoxia, and Metabolism、Cancer-related molecular mechanisms research

Objective To investigate the expression of PHD2 and HIF-1α and their clinical significance in human hepatocellular carcinoma.Methods The expression of PHD2 and HIF-1α in 80 cases of HCC were studied by immunohistochemistry assay.Results The expression of PHD2 and HIF-1α were 47.5%(38/80)and 66.3% respectively.There was no significant correlation between the expression of the two kinds of protein in HCC by Chi-square test.The increased expression of PHD2 protein is found in less differentiated HCC and is not associated with the diameter of carcinomas and metastasis.Conclusion Although PHD2 is the direct HIF gene,there are no significant relationship between the expression of the two kinds of proteins because there are more other factors to influence the expression of PHD2.In conclusion,it is possible to therapy HCC by adding the expression of PHD2,especially in less differentiated HCC.