Effect of local mild hypothermia on expression of heme oxygenase-1 following intracerebral hemorrhage in rats

作者：Mingge Shen · 发表于：Journal of Apoplexy and Nervous Diseases · 年份：2011 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Heme Oxygenase-1 and Carbon Monoxide、Neonatal and fetal brain pathology

Objective To determine whether the local mild hypothermia(LMH) diminish the volume of edema,and decrease heme oxygenase-1(HO-1) from intracerebral hemorrhage in rats.Methods One hundred and twenty male Wistar rats were randomly divided into control group and local mild hypothermia group,in which autologous arterial blood were injected into right caudate nucleus,the latter group was given local mild hypothermia for 4h after the blood injected in the brain.Results In control group,brain water content around hematoma,the permeability of blood-brain barrier(BBB) and the expression of HO-1 were significantly increased after ICH,began at 6h and peaked at 72h.HO-1 expression was positively correlated with the brain water content around hematoma and the pemeability of BBB(r=0.79 and r=0.76,respectively).Compared with ICH group,the elevation of brain water content around hematoma,BBB permeability and HO-1 expression were strongly attenuated at all time points(P0.01) in LMH group.Conclusion This study indicates that local hypothermia can significantly reduce brain edema formation after ICH by decreasing expression of HO-1.