Proton Transfer Reaction Mass Spectrometry for On-line Detection of Trace Volatile Organic Compounds in Breath

作者：Chengyin Shen, Jian-Quan LI, Hong-Zhi WANG, Zhong-Hua ZHI, Hong-Mei WANG, Chaoqun Huang, Sheng Liu, Haihe Jiang, Yannan Chu · 发表于：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION) · 年份：2012 · DOI：10.3724/sp.j.1096.2012.10983 · 被引用次数：4 · 研究领域：Advanced Chemical Sensor Technologies、Analytical Chemistry and Chromatography

Based on the independently developed proton transfer reaction mass spectrometry(PTR-MS),a new tester of volatile organic compounds(VOCs) in breath was built.The by-pass flow rate in the breath sampling inlet is controlled by mass flow controller(MFC) in this breath tester.Not only can it monitor the concentration of the concerned VOCs in real time when the MFC is opening,but detect the VOCs with full mass scan when the MFC is closed.This avoids the potential effect from the sample bag and preconcentration.The breath gas of the first author was used as the sample gas to test the performance of breath tester.The result shows that the best response time of breath tester is 1 s,and the sensitivity for acetone in breath is 14.6 counts/s per 10-9(V/V).Its repeatability is also good.The breath tester holds a potential of a wide studies in the auxiliary medical diagnosis with breath.