[The expression pattern and possible function of microRNA-34a in neurons].

作者：Yan Qi, Yu Zhao, Zhi Zhang, Dan Li, Ji Yi Gu, Xiao Nan Fu, Xiao Na Chen, Chong Yuan, Li Lai · 发表于：PubMed · 年份：2009 · 被引用次数：2 · 研究领域：MicroRNA in disease regulation

Using Northern blotting, ISH and FISH, we demonstrated miR-34a expresses with aging in the brain of rhesus monkey and rat. Correspondingly, the same trend was found in the primary cultures of cortical neurons. Moreover, we found that induction of miR-34a led to neuronal apoptosis by targeting BCL-2. Our study suggests that miR-34a may play critical roles in neuronal development and ageing.