Comparison of ACE Gene Insertion/Deletion(I/D) Polymorphism in Patients with Different Degree of Obstructive Sleep Apnea and Hypertension

作者：Pei Wei, Cams Beijing · 发表于：Chinese Journal of Hypertension · 年份：2000 · 研究领域：Obstructive Sleep Apnea Research

Objective:To compare the polymorphism of angiotensin convert enzyme(ACE) gene insertion/deletion(I/D) in the patients with different degree ofobstructive sleep apnea(OSA). Methods:Case control design.(1)The subjects were divided into four groups depending on the severity of the OSA, normal control group( n =68), HT group( n =45), HT with mild OSA group( n =27), HT with moderate and severe OSA group( n =31),174 subjects in total;(2)Analyzing distribution of ACE gene I/D allele and genotypes in a OSA family. Results: We found that the frequency of ACE gene I/D allele and genotypes were different in the four groups( P 0 001). The frequency of I allele and II genotype is significantly higher in the HT with moderate and severe OSA group than that of the other groups( P 0 001). There were no significant differences of the distribution of I allele and II genotype among the control group, the HT group and HT with mild OSA group;(3)The higher frequency of I allele and II genotype was observed in the OSA family also. Conclusion:The frequency of ACE gene I allele and II genotype were significantly related to HT with OSA patients, and inherited factors may played an important role in the etiology of OSA.