POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER III DRUG RELEASE BEHAVIOR

作者：Bei Jianzhon · 年份：1995 · 被引用次数：3 · 研究领域：biodegradable polymer synthesis and properties、Advanced Polymer Synthesis and Characterization、Synthesis and properties of polymers

The drug release behavior of degradable polymer--polycaprolactone-poly (ethyleneglycol)block copolymer(PCE) in vitro was investigated by using 5-Fluoro-uracil (5-Fu) asa model drug under a condition of pH 7. 4 at 37C. It is found that the release rate of 5-Fufrom PCE increased with increasing polyether content of the copolymer. The results showthat the increasing polyether content of the copolymer caused increasing hydrophilicity anddecreasing crystallinity of the PCE copolymer. Thus, the drug release behavior and thedegradable property of the PCE can be controlled by adjusting the composition of thecopolymer.