MicroRNA-mediated epigenetic targeting of Survivin significantly enhances the antitumor activity of paclitaxel against non-small cell lung cancer

作者：Shuiliang Wang, Ling Zhu, Weimin Zuo, Zhiyong Zeng, Lianghu Huang, Fengjin Lin, Rong Lin, Jin Wang, Jun Lü, Qinghua Wang, Lingjing Lin, Huiyue Dong, Weizhen Wu, Kai Zheng, Jinquan Cai, Shunliang Yang, Yujie Ma, Shixin Ye, Wei Liu, Yinghao Yu, Ming Jen Tan, Bolin Liu · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9264 · 被引用次数：27 · 研究领域：Epigenetics and DNA Methylation、Cell death mechanisms and regulation、Cancer-related Molecular Pathways

// Shuiliang Wang 1 , Ling Zhu 1 , Weimin Zuo 1 , Zhiyong Zeng 2 , Lianghu Huang 1 , Fengjin Lin 1 , Rong Lin 1 , Jin Wang 1 , Jun Lu 1 , Qinghua Wang 1 , Lingjing Lin 1 , Huiyue Dong 1 , Weizhen Wu 1 , Kai Zheng 1 , Jinquan Cai 1 , Shunliang Yang 1 , Yujie Ma 1 , Shixin Ye 2 , Wei Liu 3 , Yinghao Yu 3 , Jianming Tan 1 , Bolin Liu 4 1 Fujian Key Laboratory of Transplant Biology, Fuzhou General Hospital, Xiamen University, Fuzhou, Fujian, China 2 Department of Thoracic Surgery, Fuzhou General Hospital, Xiamen University, Fuzhou, Fujian, China 3 Department of Pathology, Fuzhou General Hospital, Xiamen University, Fuzhou, Fujian, China 4 Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Correspondence to: Shuiliang Wang, email: shuiliang.wang@xmu.edu.cn Jianming Tan, email: tanjm156@xmu.edu.cn Bolin Liu, email: bolin.liu@ucdenver.edu Keywords: entinostat, Survivin, miRNA, DNMT1, paclitaxel Received: January 26, 2016      Accepted: April 26, 2016      Published: May 10, 2016 ABSTRACT Elevated expression of Survivin correlates with poor prognosis, tumor recurrence, and drug resistance in various human cancers, including non-small cell lung cancer (NSCLC). The underlying mechanism of Survivin upregulation in cancer cells remains elusive. To date, no Survivin-targeted therapy has been approved for cancer treatment. Here, we explored the molecular basis resulting in Survivin o...