Clinical Observation of Xifeng Capsule for 19 Cases of Benign Childhood Epilepsy

作者：Sun Dan · 年份：2013 · 研究领域：Epilepsy research and treatment、Neuroscience and Neuropharmacology Research

Objective To observe the therapeutic effect of Xifeng Capsule(wind-extinguishing capsule) for children of benign epilepsy with centrotemporal spikes(BECTS) and the changes of electroencephalogram(EEG),determine its effective difference with Carbamazepine(CBZ) and find the better antiepileptic drugs.Methods Thirty-seven cases of BECTS from pediatric outpatients were randomized into the Xifeng Capsule group(19 cases) and CBZ group(18 cases).The Xifeng Capsule group was given Xifeng Capsule,0.99g once,three times daily.The CBZ group was given 10-20mg/kg of CBZ daily.Both groups were treated for 6 months as one observation course.The therapeutic effect was observed after treatment and EEG was examined before and after treatment.Results The total effective rate of the Xifeng Capsule group and CBZ group was 84.21% and 83.33% respectively,with no significant difference between groups(P0.05).After treatment,the epileptiform discharge frequencies of EEG in awake,slow-wave sleep and fast-wave sleep stage were significantly reduced in both groups(P0.01).The focal discharge frequency in the Xifeng Capsule group was less than that in the CBZ group,but with no significant difference between groups(P0.05).There were 15 cases(78.94%) in the Xifeng Capsule group and 11 cases(61.1%) in the CBZ group that did not occur focal discharge or declined in the frequency,but with no significant difference between groups(P0.05).There were 14 cases(73.69%) in the Xifeng Capsule group and 11 cases(61.1%) ...