Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

作者：for the ENIGMA-Major Depressive Disorder Working Group, Lianne Schmaal, Derrek P. Hibar, Philipp G. Sämann, Geoffrey B. Hall, Bernhard T. Baune, Neda Jahanshad, J. Cheung, Theo G.M. van Erp, Daniël Bos, M. Arfan Ikram, Meike W. Vernooij, Wiro J. Niessen, Henning Tiemeier, Albert Hofman, Katharina Wittfeld, Hans J. Grabe, Deborah Janowitz, Robin Bülow, M Selonke, Henry Völzke, Dominik Grotegerd, Udo Dannlowski, Volker Arolt, Nils Opel, Walter Heindel, Harald Kugel, David Hoehn, Michael Czisch, Baptiste Couvy‐Duchesne, Miguel E. Rentería, Lachlan T. Strike, Margaret J. Wright, Natalie Mills, Greig I. de Zubicaray, Katie L. McMahon, Sarah E. Medland, Nicholas G. Martin, Nathan A. Gillespie, Roberto Goya‐Maldonado, Oliver Gruber, Bernd Krämer, Sean N. Hatton, Jim Lagopoulos, Ian B. Hickie, Thomas Frodl, Angela Carballedo, Eva-Maria Frey, Laura S. van Velzen, Brenda W.J.H. Penninx, M-J van Tol, Nic J. van der Wee, Christopher G. Davey, Ben J. Harrison, Benson Mwangi, Bo Cao, Jair C. Soares, Ilya M. Veer, Henrik Walter, Dieter Schoepf, Bartosz Zurowski, Carsten Konrad, Elisabeth Schramm, Claus Normann, Knut Schnell, Matthew D. Sacchet, Ian H. Gotlib, Glenda MacQueen, Beata R. Godlewska, Thomas E. Nickson, Andrew M. McIntosh, Martina Papmeyer, Heather C. Whalley, Jérémy Hall, J. E. Sussmann, Mingzhe Li, Martin Walter, Lyubomir I. Aftanas, Ivan Brack, Н. А. Бохан, Paul M. Thompson, Dick J. Veltman · 发表于：Molecular Psychiatry · 年份：2016 · DOI：10.1038/mp.2016.60 · 被引用次数：1375 · 研究领域：Functional Brain Connectivity Studies、Treatment of Major Depression、Attention Deficit Hyperactivity Disorder

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed wides...