Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

作者：Fei-Feng Li, Peng Yan, Zhixun Zhao, Zheng Liu, Dawei Song, Xingwang Zhao, Xishan Wang, Guiyu Wang, Shu‐Lin Liu · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.9138 · 被引用次数：23 · 研究领域：Studies on Chitinases and Chitosanases、Invertebrate Immune Response Mechanisms、Parasites and Host Interactions

// Fei-Feng Li 1, 2, * , Peng Yan 3, * , Zhi-Xun Zhao 3 , Zheng Liu 4 , Da-Wei Song 3 , Xing-Wang Zhao 3 , Xi-Shan Wang 2, 4 , Gui-Yu Wang 2, 3 , Shu-Lin Liu 1, 2, 5 1 Genomics Research Center, State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin Medical University, Harbin, China 2 Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Heilongjiang, China 3 Department of Colorectal Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China 4 Department of Colorectal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 5 Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada * These authors are contributed equally to this work Correspondence to: Shu-Lin Liu, email: slliu@ucalgary.ca Gui-Yu Wang, email: guiywang@gmail.com Xi-Shan Wang, email: wxshan1208@126.com Keywords: colorectal cancer, CHIT1, C-reaction protein, gene expression, microbe Received: January 10, 2016      Accepted: April 16, 2016      Published: May 02, 2016 ABSTRACT Colorectal cancer (CRC) is one of the most common solid tumors worldwide, often associated with inflammation. The microbes in the human intestine have a key role in inflammations and CRC. Chitotriose renders growth advantage to some bacteria, especially some pathogens, and thus has a...