Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery

作者：Susanna W.L. de Geus, Leonora S. F. Boogerd, Rutger‐Jan Swijnenburg, J. Sven D. Mieog, Willemieke S. F. J. Tummers, Hendrica A.J.M. Prevoo, Cornelis F.M. Sier, Hans Morreau, Bert A. Bonsing, Cornelis J.�H. van de Velde, Alexander L. Vahrmeijer, Peter J.K. Kuppen · 发表于：Molecular Imaging and Biology · 年份：2016 · DOI：10.1007/s11307-016-0959-4 · 被引用次数：61 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Research and Treatments、Peptidase Inhibition and Analysis

PURPOSE: The purpose of this study was to identify suitable molecular targets for tumor-specific imaging of pancreatic adenocarcinoma. PROCEDURES: The expression of eight potential imaging targets was assessed by the target selection criteria (TASC)-score and immunohistochemical analysis in normal pancreatic tissue (n = 9), pancreatic (n = 137), and periampullary (n = 28) adenocarcinoma. RESULTS: , carcinoembryonic antigen (CEA), epithelial growth factor receptor (EGFR), and urokinase plasminogen activator receptor (uPAR) showed a significantly higher (all p < 0.001) expression in pancreatic adenocarcinoma compared to normal pancreatic tissue and were confirmed by the TASC score as promising imaging targets. Furthermore, these biomarkers were expressed in respectively 88 %, 71 %, 69 %, and 67 % of the pancreatic adenocarcinoma patients. CONCLUSIONS: , CEA, EGFR, and uPAR are suitable targets for tumor-specific imaging of pancreatic adenocarcinoma.