Use of Allopurinol for Prevention and Control of Hyperuricemia in Patients with Neoplastic Disease

作者：Ronald C. DeConti, Paul Calabresi · 发表于：New England Journal of Medicine · 年份：1966 · DOI：10.1056/nejm196603032740902 · 被引用次数：131 · 研究领域：Poisoning and overdose treatments、Ion channel regulation and function、Gout, Hyperuricemia, Uric Acid

UROLITHIASIS and renal insufficiency, associated with hyperuricemia, are well known complications of certain neoplastic disorders, particularly leukemia and lymphoma.1 , 2 Irradiation or chemotherapy, by increasing elevated serum levels of uric acid, may precipitate acute uric acid nephropathy. This has been cited as the most frequent cause of acute renal failure in patients with leukemia,3 and occasionally may be the presenting manifestation of the disease.4 In the past, prevention and treatment of this complication were attempted by increasing the solubility of the increased uric acid load presented to the renal tubules with vigorous hydration, urinary alkalinization and osmotic diuresis. In desperate situations . . .