Antibiotics andClostridium difficile

作者：Sherwood L. Gorbach · 发表于：New England Journal of Medicine · 年份：1999 · DOI：10.1056/nejm199911253412211 · 被引用次数：90 · 研究领域：Clostridium difficile and Clostridium perfringens research、Microscopic Colitis、Gastrointestinal motility and disorders

It is hard to remember a time in the past decades when Clostridium difficile was not a scourge in our hospitals. As a house officer in the early 1960s, I recall seeing only one patient with hospital-acquired colitis, which we called staphylococcal colitis. On the basis of what in retrospect was probably a false diagnosis, we treated the infection successfully with bacitracin, which fortuitously is active against C. difficile. Recognition of the current disease began in the early 1970s with a few isolated reports of a severe, and even lethal, colitis characterized by the formation of pseudomembranous plaques. Because of . . .