Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma

作者：Yuri E. Nikiforov, Raja R. Seethala, Giovanni Tallini, Zubair Wahid Baloch, Fulvio Basolo, Lester D.�R. Thompson, Justine A. Barletta, Bruce M. Wenig, Abir Al Ghuzlan, Kennichi Kakudo, Thomas J. Giordano, Venâncio Avancini Ferreira Alves, Elham Khanafshar, Sylvia L. Asa, Adel K. El‐Naggar, William E. Gooding, Steven P. Hodak, Ricardo V. Lloyd, Guy Maytal, Özgür Mete, Marina N. Nikiforova, Vânia Nosé, Mauro Giulio Papotti, David Nigel Poller, Peter M. Sadow, Arthur S. Tischler, Robert Michael Tuttle, Kathryn B. Wall, Virginia A. LiVolsi, Gregory William Randolph, Ronald A. Ghossein · 发表于：JAMA Oncology · 年份：2016 · DOI：10.1001/jamaoncol.2016.0386 · 被引用次数：1404 · 研究领域：Thyroid Cancer Diagnosis and Treatment、Thyroid and Parathyroid Surgery、Thyroid Disorders and Treatments

IMPORTANCE: Although growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer. OBJECTIVE: To evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological and clinical characteristics of EFVPTC. DESIGN, SETTING, AND PARTICIPANTS: International, multidisciplinary, retrospective study of patients with thyroid nodules diagnosed as EFVPTC, including 109 patients with noninvasive EFVPTC observed for 10 to 26 years and 101 patients with invasive EFVPTC observed for 1 to 18 years. Review of digitized histologic slides collected at 13 sites in 5 countries by 24 thyroid pathologists from 7 countries. A series of teleconferences and a face-to-face conference were used to establish consensus diagnostic criteria and develop new nomenclature. MAIN OUTCOMES AND MEASURES: Frequency of adverse outcomes, including death from disease, distant or locoregional metastases, and structural or biochemical recurrence, in patients with noninvasive and invasive EFVPTC diagnosed on the basis of a set of reproducible histopathologic criteria. RESULTS: Consensus diagnostic criteria for EFVPTC were developed by 24 thyroid pathologists. All of the 109 patients with noninvasive EFVPTC (67 treated with only lobectomy, none received radioactive iodine ablation) were alive with no evidence of disease at ...