Chloroquine serum concentration and side effects: Evidence for dose‐dependent kinetics

作者：Marianne Frisk‐Holmberg, Yngve Bergkvist, Britta Domeij-Nyberg, Laila Hellström, Folke Jansson · 发表于：Clinical Pharmacology & Therapeutics · 年份：1979 · DOI：10.1002/cpt1979253345 · 被引用次数：134 · 研究领域：Drug-Induced Ocular Toxicity、Peripheral Neuropathies and Disorders、Systemic Lupus Erythematosus Research

Serum concentrations of chloroquine were determined fluorometrically in 100 rheumatoid patients who had been treated with 0.25 gm daily for at least 2 mo. The total dose varied between 3.7 and 400 gm. No patient received more than 75 gm annually. In 15% of the patients side effects were noted. There was a relationship between serum concentrations and side effects but not with the total dose administered. Chloroquine displayed dose-dependent kinetics, which may indicate that close monitoring of serum concentrations is an aid to the safe and rational use of the drug.