Antimutagenic DNA Polymerases of Bacteriophage T4

作者：John W. Drake, E. F. Allen · 发表于：Cold Spring Harbor Symposia on Quantitative Biology · 年份：1968 · DOI：10.1101/sqb.1968.033.01.039 · 被引用次数：114 · 研究领域：Bacteriophages and microbial interactions、DNA Repair Mechanisms、Bacterial Genetics and Biotechnology

Mutations whose phenotype consists of an in-creased mutation rate, either throughout the genome or within some more localized region, have been discovered in a wide variety of organisms, including both procaryotes and eucaryotes. Only very recently, however, has any appreciable understanding been gained concerning mechanisms of destabilization in any of these systems. The mutations produced in E. coli by the Treffers mutator mutT have been shown to result from a highly specific transversional pathway, AT-- ~ CG (Yanofsky et al., 1966; Cox and Yanofsky, 1967). A mutator in S. typhimurium which maps near the purA locus induces miscellaneous base pair sub-stitutions, and may produce a nmtagenic base