SACCHAROMYCES CEREVISIAE INFECTIONS IN CHILDREN

作者：N. F. Fiore, James H. Conway, Karen W. West, Martin B. Kleiman · 发表于：The Pediatric Infectious Disease Journal · 年份：1998 · DOI：10.1097/00006454-199812000-00022 · 被引用次数：20 · 研究领域：Enterobacteriaceae and Cronobacter Research、Gut microbiota and health、Milk Quality and Mastitis in Dairy Cows

Saccharomyces cerevisiae, often referred to as brewer's or baker's yeast, is an ascomycetous yeast and a common plant saprophyte. Humans are frequently exposed through ingestion of foods, beverages and dietary supplements. S. cerevisiae can be a part of the normal intestinal and vaginal flora, and it rarely acts as a pathogen in humans.1 Excepting vaginitis 22 cases of clinical infection have been reported in the English language literature,2-17 the youngest of whom was 17 years old.12 Only 9 cases were associated with fungemia, with 4 patients surviving.3, 5, 6, 8, 9, 11, 13, 15 Infections are usually opportunistic.2-17 We describe 3 children with S. cerevisiae fungemia, of whom 2 survived, review previously reported fungemia cases and summarize recommendations for management. Case reports.Case 1. A 10-year-old girl with minimally symptomatic cystic fibrosis underwent evaluation for weight loss and abdominal distention during a 6-month period in 1993. She was found to have a partial bowel obstruction. Colonic biopsies showed mild inflammation and she was treated with 6-mercaptopurine and prednisone for presumed Crohn's disease. A transjugular intrahepatic portacaval shunt was required to treat refractory ascites. Six months later she was referred to the James Whitcomb Riley Hospital for Children for evaluation of malnutrition, worsening ascites and symptoms of intestinal obstruction. She had near total obstruction of the descending colon and biliary cirrhosis. During a prolo...