A Chemotactic Factor for Mononuclear Leukocytes

作者：Ralph Snyderman, H S Shin, M. Hausman · 发表于：Experimental Biology and Medicine · 年份：1971 · DOI：10.3181/00379727-138-35903 · 被引用次数：113 · 研究领域：Complement system in diseases、Cell Adhesion Molecules Research、Glycosylation and Glycoproteins Research

Chemotactic activity for mononuclear leukocytes was produced when highly purified guinea pig C5 was cleaved by trypsin or by the earlier acting complement components. This chemotactic activity was mediated by C5a, a fragmentation product of the fifth component of complement. These findings suggest a new biological function for the complement system, i.e., chemotaxis of mononuclear leukocytes, cells which are important in acute inflammation as well as wound healing.