Association between secondary thrombocytosis and viral respiratory tract infections in children

作者：Shouyan Zheng, Qiuyan Xiao, Xiaohong Xie, Yu Deng, Ren Luo, Daiyin Tian, Zhengxiu Luo, Jian Luo, Zhou Fu, Ailong Huang, Enmei Liu · 发表于：Scientific Reports · 年份：2016 · DOI：10.1038/srep22964 · 被引用次数：45 · 研究领域：Respiratory viral infections research、Parvovirus B19 Infection Studies、Platelet Disorders and Treatments

Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. The blood platelet count and the presence of respiratory viruses were determined for 3156 RTI patients, and 817 (25.9%) cases with platelet ≥500 × 10(9)/L were considered as the thrombocytosis group. Compared with the normal group, the detection rates of respiratory syncytial virus (RSV) and human rhinovirus (HRV) were significantly higher in the thrombocytosis group (P = 0.017 and 0.042, respectively). HRV single infection was a risk factor associated with thrombocytosis [odds ratio (OR) = 1.560, 95% confidence interval (CI) = 1.108-2.197]. Furthermore, ST was more likely to occur in younger patients who had clinical manifestations of wheezing and dyspnea and who had been diagnosed with bronchiolitis. Furthermore, the course of disease lasted longer in these patients. ST is associated with viral respiratory tract infections, especially RSV and HRV infections. HRV single infection is a risk factor associated with thrombocytosis.