Selenium-enriched polysaccharides from Pyracantha fortuneana (Se-PFPs) inhibit the growth and invasive potential of ovarian cancer cells through inhibiting β -catenin signaling

作者：Qian-Ling Sun, Mengmeng Dong, Zhihui Wang, Changdong Wang, Deqiao Sheng, Zhihong Li, Debin Huang, Chengfu Yuan · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.8619 · 被引用次数：41 · 研究领域：Selenium in Biological Systems、Curcumin's Biomedical Applications、Sperm and Testicular Function

// Qianling Sun 1, * , Mengmeng Dong 1, * , Zhihui Wang 2, * , Changdong Wang 3 , Deqiao Sheng 1 , Zhihong Li 1 , Debin Huang 4 , Chengfu Yuan 1 1 College of Medical Science, China Three Gorges University, Yichang, HuBei 443002, China 2 Renhe Hospital of China Three Gorges University, Yichang, HuBei 443002, China 3 Molecular Medicine & Cancer Research Center, Chongqing Medical University, Chong qing 400016, China 4 Department of Pharmacology, Hubei Institute for Nationalities, Enshi, HuBei 445000, China * These authors have contributed equally to this work Correspondence to: Chengfu Yuan, email: yuancf46@ctgu.edu.cn Keywords: selenium-enriched polysaccharides, ovarian cancer, antitumor activity, GSK-3β, β-catenin Received: December 6, 2015     Accepted: March 18, 2016     Published: April 06, 2016 ABSTRACT Polysaccharides from medicinal plants exert antitumor activity in many cancers. Our previous study demonstrated that polysaccharides extracted from the selenium-enriched Pyracantha fortuneana (Se-PFPs) showed antiproliferative effect in breast cancer cell line. This study aimed to investigate the antitumor effect of Se-PFPs in ovarian cancer cells in vitro and in vivo. Se-PFPs could decrease cell viability, induce apoptosis, and inhibit migratory and invasive potentials in HEY and SKOV3 cells. These findings are supported by reduced expression of cyclin D1, Bcl-2 and MMP-9, enhanced cleavage of PARP and caspase-3, elevat...