LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11

作者：Chenyi Jiang, Junjie Yu, Yuan Ruan, Xiaohai Wang, Wei Zhao, Xingjie Wang, Yiping Zhu, Yuan Gao, Kui‐Yuan Hao, Lei Chen, Bangmin Han, Shujie Xia, Fujun Zhao · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.8359 · 被引用次数：8 · 研究领域：Cell Adhesion Molecules Research、Immunotherapy and Immune Responses、Prostate Cancer Treatment and Research

// Chen-Yi Jiang 1, * , Jun-Jie Yu 2, * , Yuan Ruan 3 , Xiao-Hai Wang 1 , Wei Zhao 1 , Xing-Jie Wang 1 , Yi-Ping Zhu 1 , Yuan Gao 1 , Kui-Yuan Hao 1 , Lei Chen 1 , Bang-Min Han 1 , Shu-Jie Xia 1, 3 , Fu-Jun Zhao 1 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China 2 Department of Urology, Subei People’s Hospital of Jiangsu Province, Clinical Medical College of Yangzhou University, Yangzhou 225001, China 3 Department of Urology, Shanghai General Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China * These authors have contributed equally to this work Correspondence to: Fu-Jun Zhao, e-mail: drzhaofujun@yahoo.com Shu-Jie Xia, e-mail: xsjurologist@163.com Keywords: prostate cancer, stromal cell, stromal-epithelial crosstalk, LIM domain only 2 (LMO2), Interleukin-11 (IL-11) Received: November 16, 2015     Accepted: March 07, 2016     Published: March 25, 2016 ABSTRACT Mechanisms of stromal-epithelial crosstalk are essential for Prostate cancer (PCa) tumorigenesis and progression. Peripheral zone of the prostate gland possesses a stronger inclination for PCa than transition zone. We previously found a variety of genes that differently expressed among different prostate stromal cells, including LIM domain only 2 (LMO2) which highly expressed in peripheral zone derived stromal cells (PZSCs) and PCa associated fibroblasts (CAFs) compared to trans...