The New β-Lactamases

作者：George A. Jacoby, Luisa Silvia Munoz-Price · 发表于：New England Journal of Medicine · 年份：2005 · DOI：10.1056/nejmra041359 · 被引用次数：790 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Antibiotic Use and Resistance

The β-lactamases are the major bacterial defense of gram-negative bacteria against β-lactam antibiotics. This review details the many types of β-lactamases, explains how they can be detected, and summarizes information on the genetics of this form of resistance. The authors also suggest strategies for clinical management and prevention of this difficult type of antibiotic resistance.