Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3 H )-ones

作者：Xu Liu, Ning Zhang, Jiming Yang, Yongjiu Liang, Rui Zhang, Dewen Dong · 发表于：The Journal of Organic Chemistry · 年份：2013 · DOI：10.1021/jo4001959 · 被引用次数：35 · 研究领域：Chemical synthesis and alkaloids、Catalytic C–H Functionalization Methods、Synthesis and Biological Evaluation

A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6π-azaelectrocyclization. The intramolecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.