Isoflavanones from the Heartwood of Swartzia polyphylla and Their Antibacterial Activity against Cariogenic Bacteria.

作者：Kenji Osawa, Hideyuki YASUDA, Takashi MARUYAMA, Hiroshi Morita, Koichi TAKEYA, Hideji Itokawa · 发表于：Chemical and Pharmaceutical Bulletin · 年份：1992 · DOI：10.1248/cpb.40.2970 · 被引用次数：121 · 研究领域：Biological Stains and Phytochemicals、Chromatography in Natural Products、Natural product bioactivities and synthesis

The methanolic extract of Swartzia polyphylla DC. heartwood had antibacterial activity against cariogenic bacteria, the mutans Streptococci. The chromatographic purification of the extract afforded seven flavonoids. Among them, three known isoflavanones, dihydrobiochanin A, ferreirin and darbergioidin, and one new isoflavanone, 5,2',4'-trihydroxy-7-methoxyisoflavanone (dihydrocajanin) had potent antibacterial activity against cariogenic bacteria. This effect was not detected on isoflavone derivatives. A comparative antibacterial study of various flavonoids was further performed, and their structure-activity relationship was discussed.