The Mechanism of Satiety: Effect of Glucagon on Gastric Hunger Contractions in Man.

作者：A J Stunkard, Theodore B. Van Itallie, Brenda Boyd Reis · 发表于：Experimental Biology and Medicine · 年份：1955 · DOI：10.3181/00379727-89-21776 · 被引用次数：160 · 研究领域：Diet and metabolism studies、Obesity and Health Practices、Dietary Effects on Health

SummaryAdministration of glucagon intravenously to 7 normal subjects resulted in prompt abolition of gastric hunger contractions on each of 16 occasions. This was associated with decrease in the experience of hunger and coincided with a rise in blood glucose levels and an increased peripheral capillary-venous glucose difference. Fall in blood glucose levels with decreasing capillary-venous differences was associated with a return of hunger contractions and intensification of the experience of hunger in 14 of the 16 occasions. Such a pattern may be a component of the normal satiety mechanism.