Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

作者：Peter J. Barnes, Michael Karin · 发表于：New England Journal of Medicine · 年份：1997 · DOI：10.1056/nejm199704103361506 · 被引用次数：4698 · 研究领域：NF-κB Signaling Pathways、Inflammatory Bowel Disease、Cytokine Signaling Pathways and Interactions

In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.1 These activated cells produce many other mediators of inflammation.What causes these diseases is still a mystery, but the disease process results from an interplay of genetic and environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in rheumatoid arthritis and inflammatory bowel disease, may determine a patient's susceptibility to the disease and the disease's severity, but environmental factors, often unknown, . . .