Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

作者：Donald K. Ingram, Richard H. Weindruch, Edward L. Spangler, John R. Freeman, Roy L. Walford · 发表于：Journal of Gerontology · 年份：1987 · DOI：10.1093/geronj/42.1.78 · 被引用次数：343 · 研究领域：Adipose Tissue and Metabolism、Genetics and Physical Performance

Female C3B10RF1 mice maintained on either a control (approximately 95 kcal/week) or restricted (approximately 55 kcal/week) diet since weaning were tested in a behavioral battery at 11 to 15 or 31 to 35 months of age (middle-aged vs. aged). Age-related declines observed among control groups in tests of motor coordination (rotorod) and learning (complex maze) were prevented by the restriction regime. In addition, diet restriction increased locomotor activity in a runwheel cage among mice of both ages but did not affect exploratory activity in a novel arena.