Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway

作者：Liang Han, Jiguang Ma, Wanxing Duan, Lun Zhang, Shuo Yu, Qinhong Xu, Jianjun Lei, Xuqi Li, Zheng Wang, Zheng Wu, Jason H. Huang, Erxi Wu, Qingyong Ma, Zhenhua Ma · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7776 · 被引用次数：49 · 研究领域：Pancreatic and Hepatic Oncology Research、Pancreatic function and diabetes、Hedgehog Signaling Pathway Studies

// Liang Han 1 , Jiguang Ma 2 , Wanxing Duan 1 , Lun Zhang 1 , Shuo Yu 1 , Qinhong Xu 1 , Jianjun Lei 1 , Xuqi Li 3 , Zheng Wang 1 , Zheng Wu 1 , Jason H. Huang 4, 5 , Erxi Wu 4, 6 , Qingyong Ma 1 , Zhenhua Ma 1 1 Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China 2 Department of Anesthesiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China 3 Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China 4 Department of Neurosurgery, Baylor Scott and White Health Care, Temple, TX, 76508, USA 5 Department of Surgery, Texas A & M College of Medicine, Temple, TX, 76504, USA 6 Department of Pharmaceutical Sciences, Texas A & M Health Science Center, College Station, TX, 77843, USA Correspondence to: Erxi Wu, e-mail: Erxi.Wu@BSWHealth.org Qingyong Ma, e-mail: qyma56@mail.xjtu.edu.cn Zhenhua Ma, e-mail: mzh@mail.xjtu.edu.cn Keywords: pancreatic cancer, pain, pancreatic stellate cells, sHH Received: September 12, 2015      Accepted: January 05, 2016      Published: February 27, 2016 ABSTRACT Abdominal pain is a critical clinical symptom in pancreatic cancer (PC) that affects the quality of life for PC patients. However, the pathogenesis of PC pain is largely unknown. In this study, we show that PC pain is initiated by the sonic hedgehog (sHH) signaling path...