Tandem Rh-catalysis: decarboxylative β-keto acid and alkyne cross-coupling

作者：Faben A. Cruz, Zhiwei Chen, Sarah I. Kurtoic, Vy M. Dong · 发表于：Chemical Communications · 年份：2016 · DOI：10.1039/c6cc02522f · 被引用次数：96 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis

Herein, we describe a regioselective Rh-catalyzed decarboxylative cross-coupling of β-keto acids and alkynes to access branched γ,δ-unsaturated ketones. Rh-hydride catalysis enables the isomerization of an alkyne to generate a metal-allyl species that can undergo carbon-carbon bond formation. Ketones are generated under mild conditions, without the need for base or activated electrophiles.