Synthesis of Spiroaminals and Spiroketals with Bimetallic Relay Catalysis

作者：Xianghua Wang, Shuli Dong, Zhili Yao, Lei Feng, Philias Daka, Hong Wang, Zhenghu Xu · 发表于：Organic Letters · 年份：2013 · DOI：10.1021/ol4033286 · 被引用次数：102 · 研究领域：Catalytic Alkyne Reactions、Oxidative Organic Chemistry Reactions、Catalytic C–H Functionalization Methods

A novel tandem metal relay catalytic system was developed by combining gold-catalyzed cycloisomerization with an early transition-metal-catalyzed inverse-electron-demand hetero-Diels-Alder (IED-HDA) reaction. Various biologically important spiroaminals and spiroketals were obtained with very high efficiency under mild conditions.