Highly Enantioselective Copper-Catalyzed Propargylic Substitution of Propargylic Acetates with 1,3-Dicarbonyl Compounds

作者：Fuzhong Han, Fu‐Lin Zhu, Yahui Wang, Yuan Zou, Xin‐Hu Hu, Xin-Hu Hu, Song Chen, Xiang‐Ping Hu, Xiang‐Ping Hu · 发表于：Organic Letters · 年份：2013 · DOI：10.1021/ol403469m · 被引用次数：64 · 研究领域：Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods、Catalytic Alkyne Reactions

A chiral tridentate ketimine P,N,N-ligand has been successfully applied in the copper-catalyzed enantioselective propargylic substitution of propargylic acetates with a variety of β-dicarbonyl compounds, in which excellent enantioselectivities (up to >99% ee) and high yields have been obtained.