Synthesis of Key Fragments of Leiodelide A

作者：Mathieu F. Chellat, Nicolas Proust, Matthew G. Lauer, James P. Stambuli · 发表于：Organic Letters · 年份：2011 · DOI：10.1021/ol201183f · 被引用次数：16 · 研究领域：Synthetic Organic Chemistry Methods、Marine Sponges and Natural Products、Microbial Natural Products and Biosynthesis

The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from d-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner-Wadsworth-Emmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of leiodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.