Enhanced Host Defense Mechanisms with Levamisole in Suckling Rats

作者：Gerald W. Fischer, John K. Podgore, James W. Bass, James L. Kelley, Goro Kobayashi · 发表于：The Journal of Infectious Diseases · 年份：1975 · DOI：10.1093/infdis/132.5.578 · 被引用次数：59 · 研究领域：Computational Drug Discovery Methods、Viral Infections and Immunology Research、Phenothiazines and Benzothiazines Synthesis and Activities

Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.