REG4 promotes peritoneal metastasis of gastric cancer through GPR37

作者：Hexiao Wang, Lei Hu, Mingde Zang, Baogui Zhang, Yantao Duan, Zhiyuan Fan, Jianfang Li, Liping Su, Min Yan, Zhenggang Zhu, Bingya Liu, Qiumeng Yang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.8442 · 被引用次数：77 · 研究领域：Neuroendocrine Tumor Research Advances、Pancreatic and Hepatic Oncology Research、Gastric Cancer Management and Outcomes

// Hexiao Wang 1, * , Lei Hu 1, * , Mingde Zang 1 , Baogui Zhang 2 , Yantao Duan 1 , Zhiyuan Fan 1 , Jianfang Li 1 , Liping Su 1 , Min Yan 1 , Zhenggang Zhu 1 , Bingya Liu 1 , Qiumeng Yang 1 1 Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of China 2 Affiliated Hospital of Jining Medical University, Department of Surgery, Jining 272000, People’s Republic of China * These authors have contributed equally to this work Correspondence to: Qiumeng Yang, e-mail: yangqiumeng@hotmail.com Bingya Liu, e-mail: liubingya@sjtu.edu.cn Keywords: gastric cancer, peritoneal metastasis, REG4, adhesion, positive feedback Received: November 5, 2015 Accepted: March 14, 2016 Published: March 28, 2016 ABSTRACT Being the major reason of recurrence and death after surgery, peritoneal metastasis of gastric cancer dooms the prognosis of advanced gastric cancer patients. Regenerating islet-derived family, member 4 (REG4) is believed to promote peritoneal metastasis, however, its mechanism is still a moot point at present. In the present study, we show that high expression of REG4 correlates with advanced stage and poor survival prognosis for gastric cancer patients. REG4 overexpression significantly enhances peritoneal metastasis by increasing adhesion ability. Moreover, SP1 is proved to be a transcription factor of REG4 and induce REG4 expr...