The Mechanism of the Vasodilator Action of Potassium

作者：Wei‐Ting Chen, Robert A. Brace, J. B. Scott, Donald Keith Anderson, F. J. Haddy · 发表于：Experimental Biology and Medicine · 年份：1972 · DOI：10.3181/00379727-140-36560 · 被引用次数：145 · 研究领域：Cardiovascular and exercise physiology、Muscle metabolism and nutrition、Pharmacological Effects and Assays

SummaryIn the dog gracilis muscle and forelimb, ouabain blocked or reversed hypokalemic constriction and suppressed, blocked or reversed hyperkalemic vasodilation. This suggests that the vasodilator action of potassium is related to stimulation of membrane Na+ -K+ ATPase activity resulting in hyper-polarization and relaxation of the vascular smooth muscle cell. Exercise dilation was only slightly modified in a muscle in which potassium vasodilation was greatly suppressed, suggesting a minor role for potassium in sustained exercise hyperemia.