Risk Factors for Infections of the Oropharynx and the Respiratory Tract in Patients with Acute Leukemia

作者：Eberhard Kurrle, S. Bhaduri, Derk Wolfgang Krieger, Wilhelm Gaus, H. Heimpel, Horst Pflieger, R. Arnold, Ernst Vanek · 发表于：The Journal of Infectious Diseases · 年份：1981 · DOI：10.1093/infdis/144.2.128 · 被引用次数：59 · 研究领域：Neutropenia and Cancer Infections、Mycobacterium research and diagnosis、Oral health in cancer treatment

The pathogenicity of microorganisms isolated by surveillance cultures, the neutrophil count in the peripheral blood, and the interaction of the two factors were analyzed as risk factors for infections of the oropharynx and the respiratory tract in patients with acute leukemia being treated in strict reverse isolation under antimicrobial modulation. A statistical method was developed for the identification of bacteria, the presence of which was correlated with an increased risk of infection. A significantly increased risk was found mainly for species of Klebsiella, Enterobacter, Proteus, and Pseudomonas. The degree of neutropenia was significantly correlated with the risk of infection, which was influenced by the microbiologic state of the oropharynx. Thus, patients with gram negative bacilli had significantly more days with infection at all levels of neutropenia than patients without gram-negative bacilli. These two risks factors were additive but did not potentiate each other.