Fatal Severe Fever with Thrombocytopenia Syndrome: An Autopsy Case Report

作者：Natsumi Uehara, Takao Yano, Akira Ishihara, Masayuki Saijou, Tadaki Suzuki · 发表于：Internal Medicine · 年份：2016 · DOI：10.2169/internalmedicine.55.5262 · 被引用次数：39 · 研究领域：Viral Infections and Vectors、Autoimmune and Inflammatory Disorders Research、Viral Infections and Outbreaks Research

UNLABELLED: As of June 2014, among six patients who had severe fever with thrombocytopenia syndrome (SFTS) at our hospital, an 83-year-old man died despite receiving appropriate critical care. An autopsy revealed extensive ischemic damage of the intra-abdominal organs, including the liver, spleen, stomach and gut, due to severe celiac atherosclerotic stenosis and superior mesenteric arterial thrombosis. Many SFTS virus nucleoprotein antigen-immunoreactive cells were detected in a paraaortic node, where necrotizing lymphadenitis was seen, and in the spleen. Fewer such cells were seen in the liver, bone marrow and adrenals. CONCLUSION: Atherosclerosis, in addition to hemophagocytic lymphohistiocytosis syndrome, can be lethal in elderly SFTS patients.