An Hemostatic Defect Associated with Dextran Infusion

作者：John V. Carbone, Frank W. Furth, Sophie Russell, W. H. Crosby · 发表于：Experimental Biology and Medicine · 年份：1954 · DOI：10.3181/00379727-85-20798 · 被引用次数：50 · 研究领域：Hemostasis and retained surgical items、Surgical Sutures and Adhesives、Trauma, Hemostasis, Coagulopathy, Resuscitation

An hitherto undescribed hemostatic defect has been observed in normal subjects after infusion of dextran. This defect was characterized principally by a prolonged bleeding time. It was possible to produce this defect in all subjects in whom sufficient dextran was infused. The amount of 6% dextran required to produce this defect varied from 1000 to 6500 ml. Changes in plasma coagulation factors were minor and not sufficient to cause a prolonged bleeding time. The clinical significance of the hemostatic defect requires investigation.