How Can Proteins Enter the Interior of a MOF? Investigation of Cytochrome c Translocation into a MOF Consisting of Mesoporous Cages with Microporous Windows

作者：Yao Chen, Vasiliki Lykourinou, Carissa M. Vetromile, Tran Hoang, Li‐June Ming, Randy W. Larsen, Shengqian Ma · 发表于：Journal of the American Chemical Society · 年份：2012 · DOI：10.1021/ja305144x · 被引用次数：369 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Nanopore and Nanochannel Transport Studies、Supramolecular Chemistry and Complexes

It has been demonstrated for the first time that the heme protein cytochrome c (Cyt c) can enter the interior of a MOF despite the larger molecular dimension of the protein relative to the access pore sizes. Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores.