Asymmetric Dehydrogenative Cross-Coupling

作者：L.-Z. Gong, Cui-Mei Guo, Jiaxin Song, Shunrui Luo · 发表于：Synfacts · 年份：2010 · DOI：10.1055/s-0030-1258652 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis、Catalytic Cross-Coupling Reactions

Significance The ability to selectively functionalize C-H bonds in complex substrates continues to be of interest. The authors report on the copper-catalyzed asymmetric dehydrogenative cross-coupling of indolylmethyl C-H bonds with 1,3-dicarbonyl compounds. Indole derivatives feature prominently in natural products and drug targets making this strategy particularly useful.