The Utility of the Blood Pepsin Assay in Clinical Medicine

作者：Howard M. Spiro, Anna E. Ryan, Chester Morse Jones · 发表于：New England Journal of Medicine · 年份：1955 · DOI：10.1056/nejm195508182530701 · 被引用次数：56 · 研究领域：Gastroesophageal reflux and treatments、Clinical Nutrition and Gastroenterology、Gastrointestinal motility and disorders

CONVENTIONAL study of gastric secretion is limited by several factors, including the effect of the tube in the stomach. Such an unpleasant procedure may stimulate or may inhibit gastric secretion; indeed, it may be so distasteful as to preclude passage of the tube. Therefore, re-emphasis on the fact that peptic activity in the urine reflects gastric secretory activity1 stimulated much research into this more physiologic approach. Still, even urine collections were uncertain, and it was suggested that changes in water and electrolyte balance and in renal clearance might affect uropepsin excretion.Mirsky et al.,2 in 1952, described a method of . . .