UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

作者：M. Ueki, Keiichi Ueno, Shinji Miyadoh, Keiichi Abe, Kozo Shibata, Makoto Taniguchi, Susumu Oi · 发表于：The Journal of Antibiotics · 年份：1993 · DOI：10.7164/antibiotics.46.1089 · 被引用次数：123 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Genomics and Phylogenetic Studies

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.