Sedentary Behavior, Physical Activity, and Markers of Health in Older Adults

作者：Keith P. Gennuso, Ronald E. Gangnon, Charles Edwards Matthews, Keith M. Thraen-Borowski, Lisa H. Colbert · 发表于：Medicine & Science in Sports & Exercise · 年份：2013 · DOI：10.1249/mss.0b013e318288a1e5 · 被引用次数：294 · 研究领域：Physical Activity and Health、Nutrition and Health in Aging、Nutritional Studies and Diet

INTRODUCTION: The purpose of this study was to examine the association between sedentary behavior (SB), cardiometabolic risk factors, and self-reported physical function by level of moderate-vigorous physical activity (MVPA). METHODS: Cross-sectional analysis was completed on 1914 older adults age ≥ 65 yr from the 2003-2006 U.S. National Health and Nutrition Examination Survey. MVPA and SB were derived from ActiGraph accelerometers worn for 1 wk. MVPA was categorized as sufficient to meet the current U.S. guidelines (≥ 150 min · wk(-1)) or not; SB was split into quartiles. Various biomarkers were examined in laboratory analyses and physical exams, and the number of functional limitations was self-reported. Statistical interaction between SB and MVPA on the biomarker associations was the primary analysis, followed by an examination of their independent associations with relevant covariate adjustment. RESULTS: Average SB was 9.4 ± 2.3 h · d(-1) (mean ± SD), and approximately 35% were classified as sufficiently active. Overall, no significant meaningful statistical interactions were found between SB and MVPA for any of the outcomes; however, strong independent positive associations were found between SB and weight (P < 0.01), body mass index (P < 0.01), waist circumference (P < 0.01), C-reactive protein (P < 0.01), plasma glucose (P = 0.04), and number of functional limitations (P < 0.01) after adjustment for MVPA. Similarly, MVPA was negatively associated with weight (P = 0.01)...