Studies on a Glycoprotein of Fetal Calf Serum That Protects Nucleic Acids from Acid Precipitation

作者：Orpheus Antonoglou, John G. GEORGATSOS · 发表于：Experimental Biology and Medicine · 年份：1971 · DOI：10.3181/00379727-136-35492 · 被引用次数：2 · 研究领域：Animal health and immunology、T-cell and Retrovirus Studies

Fetal calf serum contains large amounts of a glycoprotein that inhibits the acid precipitation of nucleic acids. The glycoprotein has been purified by gel filtration, acetone precipitation, and polyacrylamide gel electrophoresis. Its protective activity is insensitive to extremes in pH and temperature, but sensitive to proteolytic digestion and low concentration of bivalent metals.