The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

作者：Mi Young Lim, Hyun Ju You, Hyo Shin Yoon, Bomi Kwon, Jae Yoon Lee, Sunghee Lee, Yun‐Mi Song, Kayoung Lee, Joohon Sung, GwangPyo Ko · 发表于：Gut · 年份：2016 · DOI：10.1136/gutjnl-2015-311326 · 被引用次数：366 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Adipokines, Inflammation, and Metabolic Diseases

Objective Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans. Design We characterised the gut microbial community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins and their families (n=275), of which approximately 18% (121 individuals) had MetS. We evaluated the association of MetS status with the gut microbiota and estimated the heritability of each taxon. For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene ( APOA5 ) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS. Results Individuals with MetS had a lower gut microbiota diversity than healthy individuals. The abundances of several taxa were associated with MetS status; Sutterella , Methanobrevibacter and Lactobacillus were enriched in the MetS group, whereas Akkermansia , Odoribacter and Bifidobacterium were enriched in the healthy group. Among the taxa associated with MetS status, the phylum Actinobacteria, to which Bifidobacterium belongs, had the highest heritability (45.7%). Even after adjustment for MetS status, reduc...