A Safe and Facile Route to Imidazole-1-sulfonyl Azide as a Diazotransfer Reagent

作者：Hui Ye, Ruihua Liu, Dongmei Li, Yonghui Liu, Haixin Yuan, Weikang Guo, Lifei Zhou, Xuefeng Cao, Hongqi Tian, Jie Shen, Peng George Wang · 发表于：Organic Letters · 年份：2012 · DOI：10.1021/ol3028708 · 被引用次数：61 · 研究领域：Click Chemistry and Applications、Chemical Reactions and Mechanisms、Molecular Junctions and Nanostructures

A facile approach to the diazotransfer reagent of imidazole-1-sulfonyl azide was reported. The procedure was well optimized to clarify potential explosion risks. A high production yield as well as small batch variation was achieved even without careful pretreatment of reagents and solvents. HPLC and NMR methods to monitor the process were provided. These features made this protocol suitable for large scale preparation in academia and industry as well.